Our philosophy
We believe in holistic beauty and well-being. With the highest quality standards, advanced technology, and a personalized approach, we are here to guide you on your journey to becoming your best self.
Polynucleotides from salmon DNA support the skin's own regeneration – for more elasticity, hydration and density
Injectable skin booster based on polynucleotides (PN)
Improves skin quality rather than adding volume
Three versions: HB Plus, S (scars, pores) and I (eye area)
For the face, eye area, neck, décolleté and backs of the hands
Performed by doctors after an individual medical assessment

Rejuran® places polynucleotides into the dermis in many small deposits. They bind moisture and support the fibroblasts that produce collagen and elastin. Over several weeks the skin gains elasticity and density, and the surface becomes finer. Contours and proportions stay as they are.
Treatment areas
Rejuran® works within the skin itself, not beneath it. It suits any area where the skin has become thin, dry, inelastic or uneven, including areas where fillers are not an option.
Face
We decide which one fits once we have assessed your skin
Whole face
Rejuran® HB Plus combines polynucleotides with hyaluronic acid and a local anaesthetic. For dull, dry and inelastic skin.
Acne scars & pores
Rejuran® S is more concentrated and goes directly into depressed scars and areas with enlarged pores.
Eye area
Rejuran® I is made for the thin skin under the eyes. Fine crepey lines and a tired look can be treated gently here.
Cheeks & forehead
Fine lines and uneven texture become more even, with no effect on facial expression.
Neck, décolleté & hands
Thin skin with little room for filler
Neck
Horizontal lines and thin, slack skin regain elasticity.
Décolleté
Crepey lines and sun-damaged skin become smoother and denser.
Backs of the hands
Thin, translucent skin looks stronger and better cared for.
Knees & elbows
Creased, slack skin over the joints becomes firmer and more even.
Worth knowing
Rejuran® adds no volume and changes no contours. If you want to restore hollow cheeks or temples, hyaluronic acid or a collagen biostimulator such as Sculptra® is the better choice. Which version and which areas make sense in your case is something we work out in the medical consultation.
Rejuran® is an injectable skin booster from the South Korean manufacturer PharmaResearch. Its active ingredient is polynucleotides (PN), long DNA fragments obtained from salmon and purified for medical use. They are structurally similar to human DNA and are considered well tolerated. Unlike a filler, Rejuran® fills nothing. The polynucleotides are placed in the dermis, where they bind moisture and create an environment in which the skin's own fibroblasts produce more collagen and elastin again. The result is not a visible change to the shape of the face but skin that looks more elastic, denser and more even.
Sun, environmental factors and the passing years weaken the dermis: it loses moisture, collagen and elasticity, the skin thins and the surface becomes less even. Rejuran® works in the dermis and supports the processes the skin uses to renew itself. The result builds up over several sessions.
Purified DNA fragments from salmon. They are biocompatible and are broken down by the body over time.
Polynucleotides bind water and form a stable scaffold in the tissue. The skin looks plumper after the first session.
Fibroblasts are the cells that produce collagen and elastin. Polynucleotides support their activity in the treated zone.
Newly formed fibres improve the density and firmness of the skin. Fine lines and enlarged pores stand out less.
The effect strengthens with each treatment, which is why three sessions a few weeks apart are usually planned.
HB Plus, S or I: the version, quantity and technique depend on the area, your skin and the treatment goal.
Every treatment starts with a medical consultation. We assess your skin quality, skin thickness and what you want to achieve, go through previous conditions, allergies, medication and earlier aesthetic treatments, and choose the right version of Rejuran®. Together we decide which areas to treat and roughly how many sessions will be needed.

After cleansing and disinfection we apply a numbing cream and let it take effect. Rejuran® is then placed superficially into the dermis in many small deposits with a very fine needle, or with a cannula depending on the area. Rejuran® HB Plus also contains a local anaesthetic. Including the numbing time, a session takes about 30 to 45 minutes.

Small bumps are visible at the injection points immediately after treatment. They usually flatten within one to two days. Mild redness, swelling or small bruises are possible. We recommend no make-up on the day of treatment, and avoiding sauna, tanning beds, strong sun and very intense exercise for a few days. The next session usually follows three to four weeks later.





More elastic, denser skin
Better hydration and a fresher complexion
Finer skin surface and less visible pores
Less pronounced fine lines
Smoother texture where acne scars are depressed
A fresher-looking eye area with fewer crepey lines
Better-conditioned skin on the neck, décolleté and hands
A natural result with no change to contour or expression
Results last differently from person to person, often six to twelve months
Rejuran® is injected superficially but with great precision. The choice of version, the spacing of the deposits and the injection depth determine how even the result is, particularly around the eyes. At GenClique Aesthetics the treatment is performed only by doctors and only after an individual medical assessment.
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Polynucleotides have been used in aesthetic medicine for years, and Rejuran® is among the best-known products in this group. For us it sits within bio-revitalisation, alongside mesotherapy with NCTF® and autologous blood therapy. As with any injectable treatment, the result depends on the indication, the technique and the aftercare. We reassess progress before each further session.

Rejuran® suits patients whose skin has lost elasticity, moisture and density. It does not make up for lost volume or slack contours. For that we often combine it with hyaluronic acid, Sculptra® or botulinum toxin. Which combination makes sense is something we discuss in the consultation.

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Which treatment suits you?
All four treatments aim at better skin quality rather than volume, but with different active ingredients and for different concerns. An overview, so you can bring the right question to your consultation.
This page
Polynucleotides (PN)
Polynucleotides from salmon DNA bind moisture and support the skin's own production of collagen and elastin. Three versions cover the whole face, acne scars and pores, and the eye area. For thin, inelastic and uneven skin.
Glow + hydration
NCTF® 135 HA
A cocktail of uncrosslinked hyaluronic acid, vitamins, amino acids and minerals is delivered into the skin in fine microinjections. It supplies moisture and nutrients and produces a fresher, more even complexion. A good fit for dull, tired and dry skin.
Hydration + firmness
Lightly crosslinked & stabilised hyaluronic acid
Finely distributed hyaluronic acid binds water in the skin without changing contours. The skin looks plumper and more elastic quickly, and with repeated treatments the skin quality improves too. The right choice when hydration and firmness are what's missing.
Your own blood
PDO, PLA & PLLA threads
A small amount of your blood is processed into a concentrate of platelets and growth factors, which is then delivered into the skin. Because only your own material is used, the risk of allergy is low. Suited to anyone who prefers a treatment without foreign substances.
Answers to the questions we are asked most often about Rejuran®. If yours isn't covered here, just ask us directly.
Rejuran® is an injectable skin booster based on polynucleotides (PN) obtained from salmon DNA. It adds no volume; it helps the skin bind moisture and produce more collagen and elastin again.
Rejuran® HB Plus combines polynucleotides with hyaluronic acid and a local anaesthetic. It suits treating the face, neck and décolleté across the whole area. Rejuran® S is more concentrated and goes directly into depressed acne scars and enlarged pores. Rejuran® I is made for the thin skin of the eye area. Which version fits you is something we decide once we have assessed your skin.
Hyaluronic acid fillers add volume and change contours, for example at the lips, cheeks or chin. The result is visible immediately. Rejuran® works within the skin itself and targets elasticity, density and texture. The shape of the face stays the same, and the result builds over several sessions. The two combine well.
A session usually takes 30 to 45 minutes, including the time the numbing cream needs to work. The injections themselves take about 15 to 20 minutes depending on the area.
Because many small injections are placed, you do feel the treatment. With numbing cream most patients find it easily tolerable. Rejuran® HB Plus also contains a local anaesthetic, which makes it particularly comfortable.
There is usually no real downtime. Small bumps at the injection points are typical and normally flatten within one to two days. Mild redness, swelling or small bruises are possible. If you have an important date coming up, plan the treatment a few days ahead of it.
Many patients notice fresher, better-hydrated skin after the first session. The improvement in elasticity and texture shows after a few weeks and increases with each further session. We assess the overall result once the planned course is complete.
Small bumps, redness, mild swelling, tenderness and occasional small bruises at the injection points are common and harmless. They usually settle within a few days. Infections, longer-lasting swelling or allergic reactions are rare. We go through all possible risks with you in the consultation before treatment.
Three sessions three to four weeks apart are usually planned. How many you actually need depends on your starting point, the treatment goal and the version chosen. We reassess progress before each further session.
After a completed course the result often lasts six to twelve months. How long it lasts for you depends on factors including age, skin condition, sun exposure and lifestyle. To maintain it we recommend a top-up at regular intervals.
On the day of treatment, avoid make-up and don't massage or rub the treated areas. The bumps flatten on their own. For a few days we recommend avoiding sauna, tanning beds, strong sun and very intense exercise. Consistent sun protection supports the result.
We do not treat anyone with a known allergy to fish or salmon protein or to other components of the product, anyone with acute inflammation or infection in the planned area, or during pregnancy and breastfeeding. With autoimmune conditions or a tendency to keloids we assess particularly carefully. Whether treatment is an option in your case is something we establish in the medical consultation.
Yes. Because Rejuran® improves skin quality without adding volume, it complements other treatments well. - Hyaluronic acid for volume and contour - Sculptra® for collagen building across an area - Botulinum toxin for expression lines - Morpheus8 or CO₂ laser for texture and scars What matters is the order of treatments and the interval between them. We plan both individually.
A treatment with 1 ml costs €550, whichever version is used (HB Plus, S or I). The total depends on the number of areas and sessions. Billing follows the German medical fee schedule (GOÄ). The prices given here are guide prices; the actual fee is based on the individual circumstances. You will receive a binding quote after your consultation.
Your beauty, your wellbeing, our passion. Be inspired by the experiences of our satisfied customers.
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We believe in holistic beauty and well-being. With the highest quality standards, advanced technology, and a personalized approach, we are here to guide you on your journey to becoming your best self.
